Drug interactions
Maraviroc + Nicardipine
Severity: Minor
Maraviroc and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 and P-glycoprotein substrate, and nicardipine may weakly inhibit these pathways. Any rise in maraviroc exposure is probably small, though maraviroc can cause postural hypotension, which could add to nicardipine effects.
What this interaction means in plain words
Maraviroc and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Nicardipine belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 and P-glycoprotein inhibition by nicardipine reducing maraviroc clearance.
What to do
No maraviroc dose change is needed for nicardipine, as the strong-inhibitor reduction does not apply. Monitor blood pressure and postural symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Nicardipine?
MediHelp rates the interaction as minor. Maraviroc and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc is a CYP3A4 and P-glycoprotein substrate, and nicardipine may weakly inhibit these pathways. Any rise in maraviroc exposure is probably small, though maraviroc can cause postural hypotension, which could add to nicardipine effects.
How serious is the interaction between Maraviroc and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No maraviroc dose change is needed for nicardipine, as the strong-inhibitor reduction does not apply. Monitor blood pressure and postural symptoms.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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