Drug interactions
Maraviroc + Tranylcypromine
Severity: Moderate
Maraviroc and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower blood pressure, and maraviroc is associated with postural hypotension and dizziness. Together they may increase the risk of orthostatic hypotension and falls, especially in older patients.
What this interaction means in plain words
Maraviroc and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects.
What to do
Monitor orthostatic blood pressure and counsel patients to rise slowly; reduce doses or reassess therapy if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Tranylcypromine?
MediHelp rates the interaction as moderate. Maraviroc and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower blood pressure, and maraviroc is associated with postural hypotension and dizziness. Together they may increase the risk of orthostatic hypotension and falls, especially in older patients.
How serious is the interaction between Maraviroc and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure and counsel patients to rise slowly; reduce doses or reassess therapy if symptomatic hypotension develops.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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