Drug interactions
Maraviroc + Verapamil
Severity: Moderate
Maraviroc and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise maraviroc concentrations through CYP3A4 and P-gp inhibition, increasing the risk of postural hypotension and other adverse effects. Verapamil's own blood pressure effects may add to this.
What this interaction means in plain words
Maraviroc and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maraviroc belongs to Anti Virals; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein by verapamil reduces maraviroc clearance.
What to do
Monitor for postural hypotension and dizziness. Consider reducing the maraviroc dose according to labeling if other strong CYP3A inhibitors are co-administered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Verapamil?
MediHelp rates the interaction as moderate. Maraviroc and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise maraviroc concentrations through CYP3A4 and P-gp inhibition, increasing the risk of postural hypotension and other adverse effects. Verapamil's own blood pressure effects may add to this.
How serious is the interaction between Maraviroc and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for postural hypotension and dizziness. Consider reducing the maraviroc dose according to labeling if other strong CYP3A inhibitors are co-administered.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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