Drug interactions
Maraviroc + Ziprasidone
Severity: Minor
Maraviroc and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone can cause orthostatic hypotension through alpha-1 blockade, and maraviroc has been associated with postural hypotension, especially in renal impairment. Together dizziness and falls may be more likely. The effect is usually mild.
What this interaction means in plain words
Maraviroc and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maraviroc belongs to Anti Virals; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on blood pressure regulation; no significant pharmacokinetic interaction is established.
What to do
Counsel patients to rise slowly and check orthostatic blood pressure when starting or adjusting either drug. Take extra care in patients with renal impairment or on other antihypertensives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Maraviroc with Ziprasidone?
MediHelp rates the interaction as minor. Maraviroc and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone can cause orthostatic hypotension through alpha-1 blockade, and maraviroc has been associated with postural hypotension, especially in renal impairment. Together dizziness and falls may be more likely. The effect is usually mild.
How serious is the interaction between Maraviroc and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to rise slowly and check orthostatic blood pressure when starting or adjusting either drug. Take extra care in patients with renal impairment or on other antihypertensives.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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