Drug interactions
Medroxyprogesterone + Mifepristone
Severity: Moderate
Medroxyprogesterone and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone blocks progesterone receptors and inhibits CYP3A4, which may oppose the progestogenic action of medroxyprogesterone. This could reduce contraceptive or endometrial protective effect and alter exposure.
What this interaction means in plain words
Medroxyprogesterone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Progesterone receptor antagonism by mifepristone with CYP3A4 inhibition affecting medroxyprogesterone metabolism.
What to do
Avoid relying on medroxyprogesterone for contraception or endometrial protection during mifepristone therapy. Use a non-hormonal contraceptive and review the need for the progestin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Mifepristone?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone blocks progesterone receptors and inhibits CYP3A4, which may oppose the progestogenic action of medroxyprogesterone. This could reduce contraceptive or endometrial protective effect and alter exposure.
How serious is the interaction between Medroxyprogesterone and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid relying on medroxyprogesterone for contraception or endometrial protection during mifepristone therapy. Use a non-hormonal contraceptive and review the need for the progestin.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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