Drug interactions
Medroxyprogesterone + Mitotane
Severity: Major
Medroxyprogesterone and Mitotane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong, long-lasting CYP3A4 inducer that can markedly lower medroxyprogesterone concentrations. This risks contraceptive failure or loss of therapeutic effect, and the induction persists after mitotane is stopped.
What this interaction means in plain words
Medroxyprogesterone and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Medroxyprogesterone belongs to Endocrine; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 by mitotane increases clearance of medroxyprogesterone.
What to do
Use a non-hormonal contraceptive method and keep it in place for weeks to months after stopping mitotane. If medroxyprogesterone is used for a therapeutic purpose, monitor response and consider alternatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Medroxyprogesterone and Mitotane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Medroxyprogesterone
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Medroxyprogesterone with Mitotane?
MediHelp rates the interaction as major. Medroxyprogesterone and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong, long-lasting CYP3A4 inducer that can markedly lower medroxyprogesterone concentrations. This risks contraceptive failure or loss of therapeutic effect, and the induction persists after mitotane is stopped.
How serious is the interaction between Medroxyprogesterone and Mitotane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal contraceptive method and keep it in place for weeks to months after stopping mitotane. If medroxyprogesterone is used for a therapeutic purpose, monitor response and consider alternatives.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
