Drug interactions
Medroxyprogesterone + Nicardipine
Severity: Minor
Medroxyprogesterone and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly raise medroxyprogesterone levels by inhibiting CYP3A4. A clinically significant effect is not well documented. Increased progestogenic effects are theoretically possible.
What this interaction means in plain words
Medroxyprogesterone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by nicardipine may reduce medroxyprogesterone metabolism.
What to do
No routine adjustment is needed. Monitor for progestogenic adverse effects such as bleeding changes or fluid retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Nicardipine?
MediHelp rates the interaction as minor. Medroxyprogesterone and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicardipine may modestly raise medroxyprogesterone levels by inhibiting CYP3A4. A clinically significant effect is not well documented. Increased progestogenic effects are theoretically possible.
How serious is the interaction between Medroxyprogesterone and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for progestogenic adverse effects such as bleeding changes or fluid retention.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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