Drug interactions
Medroxyprogesterone + Quinidine
Severity: Minor
Medroxyprogesterone and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may slow CYP3A4-mediated metabolism of medroxyprogesterone and increase its exposure. The clinical effect is usually limited to more progestogenic adverse effects.
What this interaction means in plain words
Medroxyprogesterone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP3A4-mediated metabolism of medroxyprogesterone.
What to do
No routine change is needed; monitor for increased progestogenic effects such as bleeding changes, fluid retention or mood changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Quinidine?
MediHelp rates the interaction as minor. Medroxyprogesterone and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinidine may slow CYP3A4-mediated metabolism of medroxyprogesterone and increase its exposure. The clinical effect is usually limited to more progestogenic adverse effects.
How serious is the interaction between Medroxyprogesterone and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for increased progestogenic effects such as bleeding changes, fluid retention or mood changes.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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