Drug interactions
Medroxyprogesterone + Rifapentine
Severity: Major
Medroxyprogesterone and Rifapentine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces drug-metabolizing enzymes and may lower medroxyprogesterone exposure. This raises the risk of contraceptive failure or reduced hormonal effect.
What this interaction means in plain words
Medroxyprogesterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Medroxyprogesterone belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 and related enzymes, increasing progestin metabolism.
What to do
Advise additional or alternative non-hormonal contraception during and after rifapentine treatment. Prefer a non-hormonal method where reliable contraception is essential.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Medroxyprogesterone
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Medroxyprogesterone with Rifapentine?
MediHelp rates the interaction as major. Medroxyprogesterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine induces drug-metabolizing enzymes and may lower medroxyprogesterone exposure. This raises the risk of contraceptive failure or reduced hormonal effect.
How serious is the interaction between Medroxyprogesterone and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise additional or alternative non-hormonal contraception during and after rifapentine treatment. Prefer a non-hormonal method where reliable contraception is essential.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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