Drug interactions
Medroxyprogesterone + Saxagliptin-metformin
Severity: Minor
Medroxyprogesterone and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Medroxyprogesterone, especially as depot injection, can reduce glucose tolerance in some patients. This may modestly weaken glycemic control in those on saxagliptin-metformin.
What this interaction means in plain words
Medroxyprogesterone and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Medroxyprogesterone belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as progestins may reduce insulin sensitivity.
What to do
Monitor glucose or HbA1c after starting or stopping the progestin and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Medroxyprogesterone and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Medroxyprogesterone, especially as depot injection, can reduce glucose tolerance in some patients. This may modestly weaken glycemic control in those on saxagliptin-metformin.
How serious is the interaction between Medroxyprogesterone and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose or HbA1c after starting or stopping the progestin and adjust antidiabetic therapy if control worsens.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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