Drug interactions
Medroxyprogesterone + Secobarbital
Severity: Moderate
Medroxyprogesterone and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may reduce medroxyprogesterone exposure. This could lessen contraceptive or therapeutic efficacy, though the clinical effect with depot injection is less well documented.
What this interaction means in plain words
Medroxyprogesterone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Medroxyprogesterone belongs to Endocrine; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturates induce hepatic CYP3A4, increasing progestin metabolism.
What to do
Consider adding a non-hormonal contraceptive method during barbiturate therapy. Monitor for breakthrough bleeding or loss of therapeutic effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Medroxyprogesterone with Secobarbital?
MediHelp rates the interaction as moderate. Medroxyprogesterone and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may reduce medroxyprogesterone exposure. This could lessen contraceptive or therapeutic efficacy, though the clinical effect with depot injection is less well documented.
How serious is the interaction between Medroxyprogesterone and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider adding a non-hormonal contraceptive method during barbiturate therapy. Monitor for breakthrough bleeding or loss of therapeutic effect.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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