Drug interactions
Mefenamic acid + Methylprednisolone
Severity: Moderate
Mefenamic acid and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a corticosteroid together with an NSAID such as mefenamic acid raises the risk of peptic ulceration and gastrointestinal bleeding. The risk is higher with higher doses and longer treatment.
What this interaction means in plain words
Mefenamic acid and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Methylprednisolone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal injury: NSAID-related prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Limit the duration of co-therapy and consider adding a proton pump inhibitor in at-risk patients. Monitor for dyspepsia and gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Mefenamic acid with Methylprednisolone?
MediHelp rates the interaction as moderate. Mefenamic acid and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a corticosteroid together with an NSAID such as mefenamic acid raises the risk of peptic ulceration and gastrointestinal bleeding. The risk is higher with higher doses and longer treatment.
How serious is the interaction between Mefenamic acid and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the duration of co-therapy and consider adding a proton pump inhibitor in at-risk patients. Monitor for dyspepsia and gastrointestinal bleeding.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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