Drug interactions
Mefenamic acid + Metolazone
Severity: Moderate
Mefenamic acid and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can diminish the diuretic and antihypertensive effects of metolazone and add to renal risk in volume-depleted patients. Fluid retention and reduced blood pressure control may result.
What this interaction means in plain words
Mefenamic acid and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, opposing the diuretic.
What to do
Monitor blood pressure, weight or edema, renal function and electrolytes. Use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Metolazone
Frequently asked questions
Can I take Mefenamic acid with Metolazone?
MediHelp rates the interaction as moderate. Mefenamic acid and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can diminish the diuretic and antihypertensive effects of metolazone and add to renal risk in volume-depleted patients. Fluid retention and reduced blood pressure control may result.
How serious is the interaction between Mefenamic acid and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight or edema, renal function and electrolytes. Use the lowest NSAID dose for the shortest time.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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