Drug interactions
Mefenamic acid + Nitazoxanide
Severity: Minor
Mefenamic acid and Nitazoxanide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolite of nitazoxanide, tizoxanide, is highly protein bound, so it could theoretically displace other highly bound drugs such as mefenamic acid. Clinical significance has not been shown and nitazoxanide is given only for short courses.
What this interaction means in plain words
Mefenamic acid and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mefenamic acid belongs to Musculoskeletal; Nitazoxanide belongs to Anti Bacterial.
Why it happens
Theoretical competition for plasma protein binding sites.
What to do
No routine action is required. Watch for increased NSAID adverse effects if both are used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Nitazoxanide
Frequently asked questions
Can I take Mefenamic acid with Nitazoxanide?
MediHelp rates the interaction as minor. Mefenamic acid and Nitazoxanide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The active metabolite of nitazoxanide, tizoxanide, is highly protein bound, so it could theoretically displace other highly bound drugs such as mefenamic acid. Clinical significance has not been shown and nitazoxanide is given only for short courses.
How serious is the interaction between Mefenamic acid and Nitazoxanide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required. Watch for increased NSAID adverse effects if both are used together.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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