Drug interactions
Mefenamic acid + Paromomycin
Severity: Minor
Mefenamic acid and Paromomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so a meaningful systemic interaction is unlikely in most patients. NSAIDs may reduce aminoglycoside clearance, a concern documented mainly in preterm infants.
What this interaction means in plain words
Mefenamic acid and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mefenamic acid belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
NSAID-related reduction in renal clearance of aminoglycosides, relevant mainly with immature renal function.
What to do
No specific action for standard oral use; monitor renal function if the patient has renal impairment or bowel inflammation that increases absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Mefenamic acid with Paromomycin?
MediHelp rates the interaction as minor. Mefenamic acid and Paromomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so a meaningful systemic interaction is unlikely in most patients. NSAIDs may reduce aminoglycoside clearance, a concern documented mainly in preterm infants.
How serious is the interaction between Mefenamic acid and Paromomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action for standard oral use; monitor renal function if the patient has renal impairment or bowel inflammation that increases absorption.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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