Drug interactions
Mefenamic acid + Vadadustat
Severity: Moderate
Mefenamic acid and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may raise vadadustat exposure, which could lead to an excessive or rapid rise in hemoglobin and associated adverse effects such as thrombotic events.
What this interaction means in plain words
Mefenamic acid and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefenamic acid belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of renal organic anion transporters OAT1/OAT3 reduces vadadustat elimination, increasing its exposure.
What to do
Monitor hemoglobin closely and adjust the vadadustat dose per labeling if hemoglobin rises too quickly. Consider an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Mefenamic acid with Vadadustat?
MediHelp rates the interaction as moderate. Mefenamic acid and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may raise vadadustat exposure, which could lead to an excessive or rapid rise in hemoglobin and associated adverse effects such as thrombotic events.
How serious is the interaction between Mefenamic acid and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely and adjust the vadadustat dose per labeling if hemoglobin rises too quickly. Consider an alternative analgesic.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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