Drug interactions
Mefloquine + Mirtazapine
Severity: Moderate
Mefloquine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine has been associated with QT prolongation, particularly in overdose or with other risk factors, and mefloquine also lengthens QT. Combined use may modestly increase the risk of ventricular arrhythmia.
What this interaction means in plain words
Mefloquine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and correct hypokalemia and hypomagnesemia; monitor for palpitations or syncope and consider an alternative antimalarial in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Mefloquine with Mirtazapine?
MediHelp rates the interaction as moderate. Mefloquine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine has been associated with QT prolongation, particularly in overdose or with other risk factors, and mefloquine also lengthens QT. Combined use may modestly increase the risk of ventricular arrhythmia.
How serious is the interaction between Mefloquine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct hypokalemia and hypomagnesemia; monitor for palpitations or syncope and consider an alternative antimalarial in patients with other QT risk factors.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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