Drug interactions
Mefloquine + Nevirapine
Severity: Moderate
Mefloquine and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine is metabolized by CYP3A4, so nevirapine may reduce its concentrations and affect prophylaxis or treatment of malaria. The effect is predicted rather than well documented.
What this interaction means in plain words
Mefloquine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induces CYP3A4, increasing mefloquine metabolism.
What to do
Consider an alternative antimalarial if prophylaxis is needed, or monitor closely for breakthrough malaria.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Mefloquine with Nevirapine?
MediHelp rates the interaction as moderate. Mefloquine and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine is metabolized by CYP3A4, so nevirapine may reduce its concentrations and affect prophylaxis or treatment of malaria. The effect is predicted rather than well documented.
How serious is the interaction between Mefloquine and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antimalarial if prophylaxis is needed, or monitor closely for breakthrough malaria.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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