Drug interactions
Mefloquine + Ozanimod
Severity: Moderate
Mefloquine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and mefloquine can prolong the QT interval and cause bradycardia, so together they may raise arrhythmia risk. Starting ozanimod in patients on QT-prolonging drugs is generally discouraged.
What this interaction means in plain words
Mefloquine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on heart rate and cardiac conduction/repolarization.
What to do
Obtain an ECG before starting ozanimod and consider cardiology advice if mefloquine is needed. Monitor heart rate and QTc during initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Mefloquine with Ozanimod?
MediHelp rates the interaction as moderate. Mefloquine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and mefloquine can prolong the QT interval and cause bradycardia, so together they may raise arrhythmia risk. Starting ozanimod in patients on QT-prolonging drugs is generally discouraged.
How serious is the interaction between Mefloquine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and consider cardiology advice if mefloquine is needed. Monitor heart rate and QTc during initiation.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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