Drug interactions
Mefloquine + Repotrectinib
Severity: Moderate
Mefloquine and Repotrectinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine inhibits P-glycoprotein and may increase repotrectinib exposure, which could increase its neurological and other adverse effects. The effect is predicted rather than well characterised clinically.
What this interaction means in plain words
Mefloquine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Repotrectinib belongs to Oncology.
Why it happens
Inhibition of P-gp efflux of repotrectinib by mefloquine.
What to do
Monitor for repotrectinib toxicity such as dizziness, ataxia and cognitive effects. Consider an alternative antimalarial if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Repotrectinib
- Apalutamide + Repotrectinib Contraindicated
- Amiodarone + Repotrectinib Major
- Amobarbital + Repotrectinib Major
- Aprepitant + Repotrectinib Major
- Armodafinil + Repotrectinib Major
- Bosentan + Repotrectinib Major
Frequently asked questions
Can I take Mefloquine with Repotrectinib?
MediHelp rates the interaction as moderate. Mefloquine and Repotrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefloquine inhibits P-glycoprotein and may increase repotrectinib exposure, which could increase its neurological and other adverse effects. The effect is predicted rather than well characterised clinically.
How serious is the interaction between Mefloquine and Repotrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for repotrectinib toxicity such as dizziness, ataxia and cognitive effects. Consider an alternative antimalarial if toxicity develops.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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