Drug interactions
Mefloquine + Rucaparib
Severity: Minor
Mefloquine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and may raise mefloquine concentrations modestly. This could increase mefloquine adverse effects such as dizziness and neuropsychiatric symptoms.
What this interaction means in plain words
Mefloquine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mefloquine belongs to Anti Parasitic; Rucaparib belongs to Oncology.
Why it happens
Weak CYP3A4 inhibition by rucaparib reduces mefloquine metabolism.
What to do
Monitor for neuropsychiatric and cardiac adverse effects of mefloquine; usually no dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Mefloquine with Rucaparib?
MediHelp rates the interaction as minor. Mefloquine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and may raise mefloquine concentrations modestly. This could increase mefloquine adverse effects such as dizziness and neuropsychiatric symptoms.
How serious is the interaction between Mefloquine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropsychiatric and cardiac adverse effects of mefloquine; usually no dose change is needed.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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