Drug interactions
Mefloquine + Sevoflurane
Severity: Moderate
Mefloquine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining mefloquine with sevoflurane anesthesia may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or underlying cardiac disease.
What this interaction means in plain words
Mefloquine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization through potassium channel effects (pharmacodynamic synergism).
What to do
Obtain a baseline ECG and correct potassium and magnesium before anesthesia in patients who recently took mefloquine. Monitor the ECG continuously during and after the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Mefloquine with Sevoflurane?
MediHelp rates the interaction as moderate. Mefloquine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combining mefloquine with sevoflurane anesthesia may raise the risk of torsades de pointes. The risk is greater with electrolyte disturbances, bradycardia or underlying cardiac disease.
How serious is the interaction between Mefloquine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before anesthesia in patients who recently took mefloquine. Monitor the ECG continuously during and after the procedure.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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