Drug interactions
Mefloquine + Stiripentol
Severity: Moderate
Mefloquine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP3A4 activity in both directions, so mefloquine exposure may change unpredictably. This may lead to either reduced antimalarial efficacy or increased adverse effects.
What this interaction means in plain words
Mefloquine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mefloquine belongs to Anti Parasitic; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibitory and inducing effects, altering mefloquine metabolism.
What to do
Monitor clinical response and tolerability of mefloquine, and consider an alternative antimalarial if the patient is on long-term stiripentol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Mefloquine with Stiripentol?
MediHelp rates the interaction as moderate. Mefloquine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP3A4 activity in both directions, so mefloquine exposure may change unpredictably. This may lead to either reduced antimalarial efficacy or increased adverse effects.
How serious is the interaction between Mefloquine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tolerability of mefloquine, and consider an alternative antimalarial if the patient is on long-term stiripentol.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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