Drug interactions
Melatonin + Nabilone
Severity: Minor
Melatonin and Nabilone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative properties that may add to the drowsiness caused by nabilone. The effect is usually modest but can affect next-day alertness.
What this interaction means in plain words
Melatonin and Nabilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive mild CNS depressant effects.
What to do
Monitor for excess daytime drowsiness and take both drugs at bedtime if they are used together. Counsel patients on caution with driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nabilone
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Melatonin with Nabilone?
MediHelp rates the interaction as minor. Melatonin and Nabilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative properties that may add to the drowsiness caused by nabilone. The effect is usually modest but can affect next-day alertness.
How serious is the interaction between Melatonin and Nabilone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess daytime drowsiness and take both drugs at bedtime if they are used together. Counsel patients on caution with driving.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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