Drug interactions
Melatonin + Temazepam
Severity: Moderate
Melatonin and Temazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic that causes sedation and can impair next-day performance. Melatonin may add to drowsiness and impairment.
What this interaction means in plain words
Melatonin and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Melatonin belongs to Gastrointestinal Tract; Temazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor for excessive sedation and impaired psychomotor function, particularly in older adults. Avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Melatonin with Temazepam?
MediHelp rates the interaction as moderate. Melatonin and Temazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temazepam is a benzodiazepine hypnotic that causes sedation and can impair next-day performance. Melatonin may add to drowsiness and impairment.
How serious is the interaction between Melatonin and Temazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and impaired psychomotor function, particularly in older adults. Avoid driving until the response is known.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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