Drug interactions
Melatonin + Vemurafenib
Severity: Minor
Melatonin and Vemurafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib is a weak to moderate CYP1A2 inhibitor, and melatonin is cleared mainly by CYP1A2. Melatonin exposure may rise, leading to stronger or longer-lasting sedation, next-day drowsiness and impaired alertness.
What this interaction means in plain words
Melatonin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Melatonin belongs to Gastrointestinal Tract; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits CYP1A2, reducing hepatic metabolism of melatonin.
What to do
Start with the lowest melatonin dose and watch for excess daytime sedation. Reduce or stop melatonin if drowsiness persists.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Vemurafenib
Frequently asked questions
Can I take Melatonin with Vemurafenib?
MediHelp rates the interaction as minor. Melatonin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vemurafenib is a weak to moderate CYP1A2 inhibitor, and melatonin is cleared mainly by CYP1A2. Melatonin exposure may rise, leading to stronger or longer-lasting sedation, next-day drowsiness and impaired alertness.
How serious is the interaction between Melatonin and Vemurafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest melatonin dose and watch for excess daytime sedation. Reduce or stop melatonin if drowsiness persists.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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