Drug interactions
Memantine + Midodrine
Severity: Minor
Memantine and Midodrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine and midodrine's active metabolite are both basic drugs secreted by renal tubular cationic transport, so competition could modestly raise levels of either. Clinical significance is unproven.
What this interaction means in plain words
Memantine and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Memantine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Competition for renal tubular cationic secretion may reduce clearance of either drug.
What to do
No routine adjustment is needed. Monitor supine blood pressure and heart rate, and watch for memantine adverse effects such as dizziness or confusion in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Memantine with Midodrine?
MediHelp rates the interaction as minor. Memantine and Midodrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine and midodrine's active metabolite are both basic drugs secreted by renal tubular cationic transport, so competition could modestly raise levels of either. Clinical significance is unproven.
How serious is the interaction between Memantine and Midodrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor supine blood pressure and heart rate, and watch for memantine adverse effects such as dizziness or confusion in patients with renal impairment.
What other medicines interact with Memantine?
MediHelp also lists interactions of Memantine with, for example, Ketamine, Acetazolamide, Aluminum hydroxide. The full list is on the Memantine page.
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