Drug interactions
Memantine-donepezil + Posaconazole
Severity: Major
Memantine-donepezil and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole prolongs the QT interval and is a strong CYP3A4 inhibitor, which may also increase donepezil exposure. Together these effects can raise the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Memantine-donepezil and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Memantine-donepezil belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition by posaconazole raising donepezil levels.
What to do
Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy. Consider an alternative antifungal or temporary donepezil dose reduction in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Memantine-donepezil with Posaconazole?
MediHelp rates the interaction as major. Memantine-donepezil and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole prolongs the QT interval and is a strong CYP3A4 inhibitor, which may also increase donepezil exposure. Together these effects can raise the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Memantine-donepezil and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc during therapy. Consider an alternative antifungal or temporary donepezil dose reduction in high-risk patients.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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