Drug interactions
Memantine-donepezil + Prochlorperazine
Severity: Moderate
Memantine-donepezil and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine is a phenothiazine that can prolong the QT interval, as can donepezil. It also has anticholinergic and dopamine-blocking effects that may counteract donepezil's benefit and worsen extrapyramidal symptoms.
What this interaction means in plain words
Memantine-donepezil and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Memantine-donepezil belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and partial muscarinic antagonism.
What to do
Use the shortest course and lowest dose of prochlorperazine, and consider an alternative antiemetic such as domperidone-free options per local practice. Check an ECG if the patient has cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Memantine-donepezil with Prochlorperazine?
MediHelp rates the interaction as moderate. Memantine-donepezil and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prochlorperazine is a phenothiazine that can prolong the QT interval, as can donepezil. It also has anticholinergic and dopamine-blocking effects that may counteract donepezil's benefit and worsen extrapyramidal symptoms.
How serious is the interaction between Memantine-donepezil and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest course and lowest dose of prochlorperazine, and consider an alternative antiemetic such as domperidone-free options per local practice. Check an ECG if the patient has cardiac risk factors.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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