Drug interactions
Meperidine + Methamphetamine
Severity: Moderate
Meperidine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs release or potentiate serotonin and catecholamines, so combined use may lead to serotonin toxicity and cardiovascular stimulation. Opposing effects on alertness make the clinical picture unpredictable.
What this interaction means in plain words
Meperidine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Methamphetamine belongs to Central Nervous System.
Why it happens
Additive serotonergic and sympathomimetic effects.
What to do
Monitor heart rate, blood pressure, temperature and neuromuscular signs. Select a non-serotonergic opioid if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Meperidine with Methamphetamine?
MediHelp rates the interaction as moderate. Meperidine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs release or potentiate serotonin and catecholamines, so combined use may lead to serotonin toxicity and cardiovascular stimulation. Opposing effects on alertness make the clinical picture unpredictable.
How serious is the interaction between Meperidine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, temperature and neuromuscular signs. Select a non-serotonergic opioid if possible.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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