Drug interactions
Meperidine + Pegvisomant
Severity: Minor
Meperidine and Pegvisomant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids have been reported to reduce the effect of pegvisomant on IGF-I in some patients with acromegaly, so disease control could be less effective. The effect is poorly characterized and not consistently shown.
What this interaction means in plain words
Meperidine and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meperidine belongs to Musculoskeletal; Pegvisomant belongs to Endocrine.
Why it happens
The mechanism is not established.
What to do
Monitor serum IGF-I when an opioid is started or stopped in a patient on pegvisomant, and adjust the pegvisomant dose according to the result.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Meperidine with Pegvisomant?
MediHelp rates the interaction as minor. Meperidine and Pegvisomant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids have been reported to reduce the effect of pegvisomant on IGF-I in some patients with acromegaly, so disease control could be less effective. The effect is poorly characterized and not consistently shown.
How serious is the interaction between Meperidine and Pegvisomant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum IGF-I when an opioid is started or stopped in a patient on pegvisomant, and adjust the pegvisomant dose according to the result.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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