Drug interactions
Meperidine + Propylhexedrine
Severity: Minor
Meperidine and Propylhexedrine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is an inhaled nasal decongestant with sympathomimetic activity and minimal sedative effects. The combination is not known to produce a significant interaction when used as directed, though pressor effects are theoretically possible if it is misused systemically.
What this interaction means in plain words
Meperidine and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Meperidine belongs to Musculoskeletal; Propylhexedrine belongs to Respiratory.
Why it happens
Theoretical opposing pharmacodynamic effects; no established mechanism.
What to do
No specific action is needed with normal inhaled use. Counsel patients not to misuse the inhaler and monitor blood pressure if large amounts are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Meperidine and Propylhexedrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Meperidine with Propylhexedrine?
MediHelp rates the interaction as minor. Meperidine and Propylhexedrine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propylhexedrine is an inhaled nasal decongestant with sympathomimetic activity and minimal sedative effects. The combination is not known to produce a significant interaction when used as directed, though pressor effects are theoretically possible if it is misused systemically.
How serious is the interaction between Meperidine and Propylhexedrine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed with normal inhaled use. Counsel patients not to misuse the inhaler and monitor blood pressure if large amounts are used.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
