Drug interactions
Meperidine + Risperidone
Severity: Moderate
Meperidine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone and meperidine produce additive sedation and orthostatic hypotension. Rare serotonin syndrome or neuroleptic malignant syndrome has been reported with antipsychotics combined with serotonergic opioids.
What this interaction means in plain words
Meperidine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible serotonergic and dopamine-blocking pharmacodynamic effects.
What to do
Monitor sedation and blood pressure and watch for features of serotonin toxicity or rigidity with fever. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Meperidine with Risperidone?
MediHelp rates the interaction as moderate. Meperidine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone and meperidine produce additive sedation and orthostatic hypotension. Rare serotonin syndrome or neuroleptic malignant syndrome has been reported with antipsychotics combined with serotonergic opioids.
How serious is the interaction between Meperidine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure and watch for features of serotonin toxicity or rigidity with fever. Reduce doses if excessive sedation occurs.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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