Drug interactions
Meperidine + Sevoflurane
Severity: Moderate
Meperidine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids reduce the concentration of volatile anesthetic needed and add to respiratory depression and hypotension. The effect is expected and is managed in routine anesthesia practice.
What this interaction means in plain words
Meperidine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression via different pharmacological mechanisms.
What to do
Titrate sevoflurane to effect and monitor ventilation, oxygenation and hemodynamics continuously. Anticipate prolonged postoperative respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Meperidine with Sevoflurane?
MediHelp rates the interaction as moderate. Meperidine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids reduce the concentration of volatile anesthetic needed and add to respiratory depression and hypotension. The effect is expected and is managed in routine anesthesia practice.
How serious is the interaction between Meperidine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to effect and monitor ventilation, oxygenation and hemodynamics continuously. Anticipate prolonged postoperative respiratory depression.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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