Drug interactions
Meperidine + Stiripentol
Severity: Moderate
Meperidine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and, with meperidine, may add to central nervous system depression. Stiripentol also inhibits several CYP enzymes, which may change meperidine metabolism.
What this interaction means in plain words
Meperidine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Meperidine belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible CYP inhibition by stiripentol affecting meperidine clearance.
What to do
Monitor for increased sedation and respiratory depression and start the opioid at a reduced dose. Adjust therapy if neurotoxicity such as tremor occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Meperidine with Stiripentol?
MediHelp rates the interaction as moderate. Meperidine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and, with meperidine, may add to central nervous system depression. Stiripentol also inhibits several CYP enzymes, which may change meperidine metabolism.
How serious is the interaction between Meperidine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and respiratory depression and start the opioid at a reduced dose. Adjust therapy if neurotoxicity such as tremor occurs.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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