Drug interactions
Metaxalone + Metoclopramide
Severity: Moderate
Metaxalone and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, and metoclopramide may also cause extrapyramidal reactions. Used together, sedation and impaired alertness may be more pronounced.
What this interaction means in plain words
Metaxalone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression.
What to do
Warn patients about additive sedation and avoid driving or hazardous tasks until tolerance is established. Use the lowest effective doses and limit duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Metaxalone
Frequently asked questions
Can I take Metaxalone with Metoclopramide?
MediHelp rates the interaction as moderate. Metaxalone and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, and metoclopramide may also cause extrapyramidal reactions. Used together, sedation and impaired alertness may be more pronounced.
How serious is the interaction between Metaxalone and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about additive sedation and avoid driving or hazardous tasks until tolerance is established. Use the lowest effective doses and limit duration.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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