Drug interactions
Metaxalone + Propofol
Severity: Moderate
Metaxalone and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic, and metaxalone may add to its CNS depressant effect. This can deepen sedation and increase the risk of respiratory depression and hypotension during procedural or ICU sedation.
What this interaction means in plain words
Metaxalone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Metaxalone belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Titrate propofol carefully to the sedation target and monitor respiratory status and blood pressure continuously. Expect lower propofol requirements in patients who have recently taken metaxalone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Propofol
Frequently asked questions
Can I take Metaxalone with Propofol?
MediHelp rates the interaction as moderate. Metaxalone and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propofol is a potent sedative-hypnotic, and metaxalone may add to its CNS depressant effect. This can deepen sedation and increase the risk of respiratory depression and hypotension during procedural or ICU sedation.
How serious is the interaction between Metaxalone and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully to the sedation target and monitor respiratory status and blood pressure continuously. Expect lower propofol requirements in patients who have recently taken metaxalone.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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