Drug interactions
Metaxalone + Teriflunomide
Severity: Minor
Metaxalone and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C8 and weakly induces CYP1A2, and metaxalone is metabolized by several CYP enzymes including CYP1A2. Exposure to metaxalone could change, but the direction and magnitude are not well characterized.
What this interaction means in plain words
Metaxalone and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Metaxalone belongs to Musculoskeletal; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide may modulate CYP1A2 and CYP2C8 activity, altering metaxalone metabolism; the effect is not firmly established.
What to do
Monitor for reduced muscle relaxant effect or increased drowsiness when starting or stopping teriflunomide. No dose adjustment is routinely required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metaxalone
Other interactions of Teriflunomide
Frequently asked questions
Can I take Metaxalone with Teriflunomide?
MediHelp rates the interaction as minor. Metaxalone and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide inhibits CYP2C8 and weakly induces CYP1A2, and metaxalone is metabolized by several CYP enzymes including CYP1A2. Exposure to metaxalone could change, but the direction and magnitude are not well characterized.
How serious is the interaction between Metaxalone and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced muscle relaxant effect or increased drowsiness when starting or stopping teriflunomide. No dose adjustment is routinely required.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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