Drug interactions
Methamphetamine + Midazolam
Severity: Minor
Methamphetamine and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is a stimulant and may partly oppose midazolam sedation, but the net effect is unpredictable. Stimulant effects may also mask sedation without reducing the impairment from the benzodiazepine.
What this interaction means in plain words
Methamphetamine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methamphetamine belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on central nervous system arousal; no established pharmacokinetic interaction.
What to do
Titrate midazolam to clinical effect rather than assuming reduced sedation, and monitor heart rate, blood pressure and respiratory status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Midazolam?
MediHelp rates the interaction as minor. Methamphetamine and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methamphetamine is a stimulant and may partly oppose midazolam sedation, but the net effect is unpredictable. Stimulant effects may also mask sedation without reducing the impairment from the benzodiazepine.
How serious is the interaction between Methamphetamine and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical effect rather than assuming reduced sedation, and monitor heart rate, blood pressure and respiratory status.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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