Drug interactions
Methamphetamine + Mirabegron
Severity: Moderate
Methamphetamine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methamphetamine is partly metabolised by CYP2D6, so mirabegron may increase exposure. Both drugs can raise blood pressure and heart rate, so combined cardiovascular effects are possible.
What this interaction means in plain words
Methamphetamine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6 and has additive pressor effects with sympathomimetics.
What to do
Monitor blood pressure and heart rate, and reduce the methamphetamine dose or review therapy if hypertension or tachycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Methamphetamine with Mirabegron?
MediHelp rates the interaction as moderate. Methamphetamine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methamphetamine is partly metabolised by CYP2D6, so mirabegron may increase exposure. Both drugs can raise blood pressure and heart rate, so combined cardiovascular effects are possible.
How serious is the interaction between Methamphetamine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and reduce the methamphetamine dose or review therapy if hypertension or tachycardia develops.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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