Drug interactions
Methamphetamine + Perphenazine
Severity: Moderate
Methamphetamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine inhibits CYP2D6 and may raise methamphetamine levels, and its dopamine blockade opposes the stimulant's effects. Both can affect cardiac conduction or heart rate, adding to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Methamphetamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by perphenazine plus opposing dopaminergic pharmacodynamics and additive cardiac effects.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors. Adjust methamphetamine dose if signs of stimulant excess occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Methamphetamine with Perphenazine?
MediHelp rates the interaction as moderate. Methamphetamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine inhibits CYP2D6 and may raise methamphetamine levels, and its dopamine blockade opposes the stimulant's effects. Both can affect cardiac conduction or heart rate, adding to arrhythmia risk in susceptible patients.
How serious is the interaction between Methamphetamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac risk factors. Adjust methamphetamine dose if signs of stimulant excess occur.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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