Drug interactions
Methamphetamine + Tipranavir
Severity: Moderate
Methamphetamine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is co-administered with ritonavir, which inhibits CYP2D6 and could raise methamphetamine exposure. The effect on methamphetamine concentrations has not been well characterized, but increased stimulant and cardiovascular effects are possible.
What this interaction means in plain words
Methamphetamine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methamphetamine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Possible inhibition of CYP2D6-mediated methamphetamine metabolism by the ritonavir-boosted regimen.
What to do
Monitor blood pressure, heart rate and stimulant adverse effects. Lower the methamphetamine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Methamphetamine with Tipranavir?
MediHelp rates the interaction as moderate. Methamphetamine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir is co-administered with ritonavir, which inhibits CYP2D6 and could raise methamphetamine exposure. The effect on methamphetamine concentrations has not been well characterized, but increased stimulant and cardiovascular effects are possible.
How serious is the interaction between Methamphetamine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and stimulant adverse effects. Lower the methamphetamine dose if toxicity appears.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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