Drug interactions
Methocarbamol + Metoclopramide
Severity: Moderate
Methocarbamol and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness and dizziness. Taken together they may produce more sedation and impaired concentration than either alone.
What this interaction means in plain words
Methocarbamol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methocarbamol belongs to Musculoskeletal; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression.
What to do
Advise patients about increased sedation and avoid driving until response is known. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Methocarbamol
Frequently asked questions
Can I take Methocarbamol with Metoclopramide?
MediHelp rates the interaction as moderate. Methocarbamol and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness and dizziness. Taken together they may produce more sedation and impaired concentration than either alone.
How serious is the interaction between Methocarbamol and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about increased sedation and avoid driving until response is known. Use the lowest effective doses.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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