Drug interactions
Methocarbamol + Propofol
Severity: Moderate
Methocarbamol and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methocarbamol may potentiate the sedative and respiratory depressant effects of propofol. This is relevant during anesthesia or procedural sedation, where deeper than intended sedation and hypotension can occur.
What this interaction means in plain words
Methocarbamol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methocarbamol belongs to Musculoskeletal; Propofol belongs to Central Nervous System.
Why it happens
Additive central nervous system and respiratory depression through pharmacodynamic synergism.
What to do
Titrate propofol to effect with the lowest necessary dose and monitor respiratory function and blood pressure continuously. Inform the anesthesia team about recent methocarbamol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Methocarbamol and Propofol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Methocarbamol
Other interactions of Propofol
Frequently asked questions
Can I take Methocarbamol with Propofol?
MediHelp rates the interaction as moderate. Methocarbamol and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methocarbamol may potentiate the sedative and respiratory depressant effects of propofol. This is relevant during anesthesia or procedural sedation, where deeper than intended sedation and hypotension can occur.
How serious is the interaction between Methocarbamol and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with the lowest necessary dose and monitor respiratory function and blood pressure continuously. Inform the anesthesia team about recent methocarbamol use.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
