Drug interactions
Methohexital + Metoclopramide
Severity: Moderate
Methohexital and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has CNS depressant effects and can reduce the dose of anesthetic induction agents needed. Combined with methohexital, deeper or longer sedation and hemodynamic depression may occur.
What this interaction means in plain words
Methohexital and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression; metoclopramide is reported to lower anesthetic requirements.
What to do
Titrate methohexital to effect with continuous monitoring of airway, ventilation and blood pressure. Expect a lower dose requirement.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Metoclopramide?
MediHelp rates the interaction as moderate. Methohexital and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide has CNS depressant effects and can reduce the dose of anesthetic induction agents needed. Combined with methohexital, deeper or longer sedation and hemodynamic depression may occur.
How serious is the interaction between Methohexital and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect with continuous monitoring of airway, ventilation and blood pressure. Expect a lower dose requirement.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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