Drug interactions
Methohexital + Prochlorperazine
Severity: Moderate
Methohexital and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic, and prochlorperazine adds sedation and hypotension. The combination can deepen CNS depression and cause respiratory depression and cardiovascular instability.
What this interaction means in plain words
Methohexital and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from barbiturate GABA-A potentiation and phenothiazine sedative and alpha-blocking effects.
What to do
Reduce the methohexital dose as needed and titrate to effect. Monitor airway, respiration and blood pressure in a setting equipped for ventilatory support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Prochlorperazine?
MediHelp rates the interaction as moderate. Methohexital and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic, and prochlorperazine adds sedation and hypotension. The combination can deepen CNS depression and cause respiratory depression and cardiovascular instability.
How serious is the interaction between Methohexital and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the methohexital dose as needed and titrate to effect. Monitor airway, respiration and blood pressure in a setting equipped for ventilatory support.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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