Drug interactions
Methohexital + Propofol
Severity: Moderate
Methohexital and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are intravenous general anesthetics that enhance GABA-A activity, so combined use produces additive sedation, hypotension and respiratory depression. Dose requirements of each drug fall when they are given together.
What this interaction means in plain words
Methohexital and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methohexital belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor-mediated CNS depression.
What to do
Reduce and titrate doses of each agent, and provide continuous monitoring of oxygenation, ventilation and blood pressure with airway support available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Methohexital
Frequently asked questions
Can I take Methohexital with Propofol?
MediHelp rates the interaction as moderate. Methohexital and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are intravenous general anesthetics that enhance GABA-A activity, so combined use produces additive sedation, hypotension and respiratory depression. Dose requirements of each drug fall when they are given together.
How serious is the interaction between Methohexital and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce and titrate doses of each agent, and provide continuous monitoring of oxygenation, ventilation and blood pressure with airway support available.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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