Drug interactions
Methoxsalen + Prochlorperazine
Severity: Moderate
Methoxsalen and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of severe phototoxic reactions such as burns.
What this interaction means in plain words
Methoxsalen and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methoxsalen belongs to Anti Fungals; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive photosensitizing effects.
What to do
Monitor skin response and adjust the UVA dose conservatively. Counsel on strict sun protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Methoxsalen with Prochlorperazine?
MediHelp rates the interaction as moderate. Methoxsalen and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines can cause photosensitivity, and methoxsalen is a potent photosensitizer used with UVA exposure. Together they may increase the risk of severe phototoxic reactions such as burns.
How serious is the interaction between Methoxsalen and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor skin response and adjust the UVA dose conservatively. Counsel on strict sun protection.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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