Drug interactions
Methylprednisolone + Midazolam
Severity: Minor
Methylprednisolone and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylprednisolone may weakly induce CYP3A4 and reduce midazolam exposure, though a clinically important effect is uncertain. Any change in sedation is likely to be small.
What this interaction means in plain words
Methylprednisolone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Methylprednisolone belongs to Endocrine; Midazolam belongs to Central Nervous System.
Why it happens
Possible weak induction of CYP3A4 by methylprednisolone increasing midazolam metabolism.
What to do
Titrate midazolam to clinical sedation effect as usual. No pre-emptive dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Methylprednisolone with Midazolam?
MediHelp rates the interaction as minor. Methylprednisolone and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methylprednisolone may weakly induce CYP3A4 and reduce midazolam exposure, though a clinically important effect is uncertain. Any change in sedation is likely to be small.
How serious is the interaction between Methylprednisolone and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate midazolam to clinical sedation effect as usual. No pre-emptive dose change is needed.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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