Drug interactions
Methylprednisolone + Nabumetone
Severity: Moderate
Methylprednisolone and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a corticosteroid with nabumetone increases the risk of gastric ulceration and gastrointestinal bleeding. Nabumetone is a prodrug with comparatively lower GI toxicity, but the additive risk still applies.
What this interaction means in plain words
Methylprednisolone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methylprednisolone belongs to Endocrine; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury: NSAID-related prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest time, and consider a proton pump inhibitor in at-risk patients. Monitor for gastrointestinal bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Methylprednisolone with Nabumetone?
MediHelp rates the interaction as moderate. Methylprednisolone and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a corticosteroid with nabumetone increases the risk of gastric ulceration and gastrointestinal bleeding. Nabumetone is a prodrug with comparatively lower GI toxicity, but the additive risk still applies.
How serious is the interaction between Methylprednisolone and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time, and consider a proton pump inhibitor in at-risk patients. Monitor for gastrointestinal bleeding.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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